Formulation of Bioerodible Ketamine Microparticles as an Analgesic Adjuvant Treatment Produced by Supercritical Fluid Polymer Encapsulation
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چکیده
منابع مشابه
Polymer Encapsulation of Fine Particles by a Supercritical Antisolvent Process
Coating and encapsulation of fine particles with polymer using a supercritical antisolvent (SAS) coating process was investigated in this research. Synthesized submicron silica particles were used as host particles and poly(lactide-co-glycolide) (PLGA), a biodegradable polymer used for controlled release of drugs, was chosen as the coating material. In the SAS coating process a suspension of si...
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Ketamine, in subanesthetic doses, produces systemic analgesia in chronic pain settings, an action largely attributed to block of N-methyl-D-aspartate receptors in the spinal cord and inhibition of central sensitization processes. N-methyl-D-aspartate receptors also are located peripherally on sensory afferent nerve endings, and this provided the initial impetus for exploring peripheral applicat...
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glichkeiten. Angewandte Chemie 105: 659; Angewandte Chemie, International Edition English 32: 629. Francuskiewicz F (1994) Polymer Fractionation (Springer Lab Manual). Heidelberg: Springer Verlag. GloK ckner G (1987) Polymer Characterization by Liquid Chromatography. Amsterdam: Elsevier. GloK ckner G (1991) Gradient HPLC of copolymers and chromatographic cross fractionation. Berlin: Springer Ve...
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Animal studies on ketamine and opioid tolerance have shown promising results. Clinical trials have been contradictory. We performed a systematic review of randomized, double-blind clinical trials of ketamine added to opioid analgesia. Thirty-seven trials with 51 treatment arms and 2385 patients were included. Studies were divided into 5 subgroups: IV ketamine as single dose (n = 11), continuous...
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BACKGROUND Caffeine's properties as an analgesic adjuvant with nonsteroidal anti-inflammatory drugs/acetaminophen are well documented. However, little clinical research has explored caffeine's effects on opioid analgesia. This study assessed the effects of caffeine consumption on pain and other symptoms in opioid-using and nonusing chronic pain patients meeting the survey criteria for fibromyal...
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ژورنال
عنوان ژورنال: Pharmaceutics
سال: 2018
ISSN: 1999-4923
DOI: 10.3390/pharmaceutics10040264